The clubs and partys link show there are two quite well established clubs in Manchester, Cupidsand Adam & Eves which have a decent number of reviews and as they're local to you, they'll be a pretty good place to start?
There's also Club Kinkyin Lpool, though the one time I went there , it was literally empty but for me ... I reckon everyone was still down about England not getting through the Euro 2004 quarter final ... facilities looked really good though. If anyone here has been there before, I'd be interested to hear what it's like on an average night as I'd like to go there again next time I'm in Lpool.
I could recommend several clubs and several different nights, but as you haven't said what you're looking for specifically, it's a tad difficult to advise you!